RUNX2 and acute lymphoblastic leukemia: We recently reported that Runt-related transcription factor 2 (RUNX2) was upregulated in children, adolescents, and young adults with high-risk T-ALL and its increased expression was associated with leukemic cell migration and dissemination of T-ALL to extramedullary sites including the meninges (Matthijssens et al., 2021).