To investigate if DDR1b and DDR2 signal through differential pathways in HT1080 xenografts, the authors checked the status of the mitogen-activated protein kinase (MAPK), AKT/PI3K and the Hippo pathways in tumours formed by DDR expressing HT1080 cells embedded within collagen I gels (COLI). Here, AKT1 is linked to neoplasm.