To investigate the signalling pathways downstream of integrin α10 subunit that drive growth in myxofibrosarcoma cells, the authors showed that the nucleotide exchange factor, triple functional domain protein (TRIO), and the subunit of the mTORC2 complex, rapamycin-insensitive companion of mammalian target of rapamycin (RICTOR) are direct binding partners of integrin α10 subunit. Here, TRIO is linked to myxofibrosarcoma.