The similarity in laminin staining between normal adipose tissue, benign lipomas and well-differentiated liposarcoma, which generally have good clinical outcome, and heterogeneity in laminin expression patterns in myxoid liposarcomas, and lack of laminin in highly malignant pleomorphic liposarcomas might indicate that laminin has a role in the malignant transformation of adipocytes. This evidence concerns the gene LAMB2 and lipoma.