Previous studies established the cross-talk between USP10 and fibrosis in multiple tissues, which are down-regulated in cancers, Parkinson disease (PD), and keloids, and specifically render the heart susceptible to hypertrophy injury (Anisimov et al., 2019; Deng et al., 2019; Boumil et al., 2020; Zhang et al., 2020). Here, USP10 is linked to keloid.