Further, Wei et al. applied an epicardial patch with human FSTL1 protein to rescue cardiac dysfunction in swine and mouse MI models through inhibition of myocardial fibrosis (Wei et al., 2015; Shen et al., 2019; Hu et al., 2020; Xi et al., 2020). The gene discussed is FSTL1; the disease is Myocardial fibrosis.