NOTCH1 and Myocardial fibrosis: Numerous studies have confirmed that Notch1 upregulation inhibited myocardial fibrosis in animal MI models whereas, Notch1 inhibition worsened cardiac dysfunction by increasing myocardial fibrosis in both MI injured hearts and in diabetic heart (Russell et al., 2011; Yu et al., 2018; Zhou et al., 2019; Xuan et al., 2020).