TET1 and neoplasm: For instance, TET1 has been considered as a critical oncogenic epigenetic regulator in acute myeloid leukemia (AML), which plays its role by promoting the expression of oncogenic targets, including HOXA9, MEIS1 and PBX3, and suppressing the expression of tumor suppressor miR-22 (Huang et al., 2013; Huang et al., 2016; Jiang et al., 2016).