One study demonstrates that the 5hmC landscape in pancreatic ductal adenocarcinoma (PDAC) peaks in the gene that encodes the bromodomain-containing transcription factor BRD4, overlapping with active enhancer marks such as H3K4me1, and 5hmC acquisition by BRD4 enhancer is found to be a potential mechanism for regulating oncogenic activation (Bhattacharyya et al., 2017). This evidence concerns the gene BRD4 and pancreatic ductal adenocarcinoma.