TMIGD2 and colorectal cancer: In human colorectal cancer cells, immunoglobulin-containing and proline-rich receptor-1 (IGPR-1), which mediates endothelial barrier function and cell-to-cell interaction, is upregulated and increases survival under chemotherapeutics such as SB203580, a p38 inhibitor, by causing multicellular aggregation (Figure 3B) (Woolf et al., 2017).