For example, activated FAK by vascular endothelial growth factor (VEGF) directly phosphorylates tyrosine residue of vascular endothelial cadherin (VEC-Y658), located at the cell junctions, which results in enhanced permeability of the endothelial cells by transmitting tumor cells through the attenuated cell-cell junctions (Jean et al., 2014). The gene discussed is VEGFA; the disease is neoplasm.