TP53 and colonic neoplasm: For instance, by using the p53 wild-type HCT116 human colon cancer cell line, Suzuki and others determined that p53 wt can enhance the post-transcriptional maturation of several miRNAs with a growth-suppressive function such as miR-143 and miR-16-1 that target K-Ras, and miR-145 which targets CDK6 in response to DNA damage.