Our previous studies identified differential expression of Zbtb1 in pancreatic cancer (Cheng et al., 2021a); a reciprocal inhibitory role between IL-7Rα signalling (Cao et al., 2018); protection of genomic integrity and prevention of p53-mediated apoptosis in proliferating lymphoid progenitor cells (Cao et al., 2016); and differential expression of microRNA and circRNA in Zbtb1 knockdown monoclonal EL4 cells (Wang et al., 2021). The gene discussed is TP53; the disease is familial pancreatic carcinoma.