There was a significant association between MEG3 gene rs7158663 polymorphism and CRC susceptibility [GA vs. GG: OR=1.48, 95%CI= 1.11-1.96, P=0.007; AA vs. GG: OR=1.83, 95%CI=1.11-3.03, P=0.018; (GA+AA) vs. GG: OR=1.53, 95%CI=1.17-2.00, P=0.002; A vs. G: OR=1.41, 95%CI=1.14-1.74, P=0.001]. The gene discussed is MEG3; the disease is colorectal carcinoma.