For instance, concentration of sevoflurane from 1.7% to 5.1% significantly inhibits invasion and migration of lung carcinoma cells by decreasing the phosphorylation of p-38 MAPK, reducing HIF-1α activation and downregulating matrix metallopeptidases (MMP) 2 and MMP-9 (69–71). This evidence concerns the gene HIF1A and lung carcinoma.