Although hypoxic MES-like cells were more malignant in inner tumor cell interaction such as invasiveness mediated by CD44-related interaction (38), proliferation induced by EGFR- and MIF-related interactions (40), and angiogenesis activated by VEGF-related interaction, other tumor cell subtypes under hypoxia performed more or less similar manners (Figure 2D). Here, MIF is linked to neoplasm.