EGFR and neoplasm: To uncover the relationship between hypoxia status and these four tumor cell subtypes, we analyzed the autocrine signaling under different hypoxia status and found that MES-like subtype with hypoxia sent out more epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), and fibroblast growth factor receptor (FGFR) signal to itself, indicating that it was more proliferative and invasive than others (Figure 2D).