Otherwise, tumor cells in hypoxia could inhibit TAMs activation via HLA-G/LILRB interactions (Supplementary Figure S3C), assist TAMs polarization via CD44-related communication (Figure 4E and Supplementary Figure S3C), and inhibit T-cell activation via PDCD1 and TIGIT (Figure 4F and Supplementary Figure S3B). The gene discussed is PDCD1; the disease is neoplasm.