Multi-targeted kinase inhibitor GNF-7 (26) and its derivatives are shown to be able to suppress proliferation of both Ba/F3 cells transformed with NRAS-G12D and human AML cell lines, OCI-AML3 (NRAS-Q61L) via dual inhibition of ACK1 and GCK. This evidence concerns the gene TNK2 and acute myeloid leukemia.