In accordance with the observation form anti-proliferative activities against Ba/F3 cells transformed with mtRAS (NRAS-G12D and NRAS-G12V), derivatives with modified substituents (compounds 2–4 and SIJ1795) showed 2 to 11-fold increased anti-proliferative activities against all cancer cells harboring mtRAS compared with GNF-7. This evidence concerns the gene NRAS and cancer.