Further survival analysis of the four TRIM proteins in HCC patients (http://kmplot.com/analysis/index.php?p=service&cancer=liver_rnaseq) showed that a higher TRIM54 expression was associated not only with a shorter overall survival time (HR=2.26, p < 0.001) but also with progression-free survival time (HR=1.54, P = 0.009) and relapse-free survival time (HR=1.50, P = 0.027) compared with a lower TRIM54 expression in HCC patients (Figure 1B), but not TRIM31 and TRIM22 (Supplemental Figure 1A). Here, TRIM22 is linked to hepatocellular carcinoma.