TRIM54 and hepatocellular carcinoma: The correlation between TRIM54 expression and wnt/β-catenin activation was further determined by using gene set enrichment analysis (GSEA), which showed that TRIM54 overexpression was significantly associated with gene signature-related wnt/β-catenin activation in HCC (Figure 4C), suggesting that TRIM54 might contribute to modulate wnt/β-catenin signaling.