Among them (Figure 1A), TRIM54, TRIM31, and TRIM28 showed significant overexpression in GSE54238 (advanced HCC vs. early HCC > 1.5, p < 0.05), TCGA (HCC vs. normal > 1.5, p < 0.05), and GSE20140 (HCC tissues vs. chronic tissues > 1.5, p < 0.05) and an mRNA expression of the top 20 TRIM proteins in 100 primaries and matched non-malignant tissues of HCC patients; however, TRIM22 was downregulated in the above multiple published profiles (T/N<0.5, p < 0.05). The gene discussed is TRIM28; the disease is hepatocellular carcinoma.