Similar to the effect of β-catenin silencing in TRIM54 overexpression cells, treatment with ICG-001, a specific inhibitor of β-catenin signaling via blockage of β-catenin/CBP interaction, also significantly decreased the effect of TRIM54 on HCC proliferation and metastasis (Figures 6A–C). Here, TRIM54 is linked to hepatocellular carcinoma.