In the present study, we examined the effects of optimally timed paclitaxel for the treatment of two cancer cell lines: (1) the human brain seeking Her2+ breast carcinoma cell line, JIMT-1BR3-GFP-Luc and (2) the murine brain seeking breast carcinoma cell line, 4T1-BR5-Luc. Here, ERBB2 is linked to cancer.