MCAM and nonpapillary renal cell carcinoma: Consistently, CpG sites of CD146, including cg08187057, cg09042577, cg25484790, cg18890215, cg24827784, cg14976391, and cg17466841, showed higher methylation levels in ccRCC, indicating that the CD146 methylation in these CpG sites was correlated with poor prognosis in ccRCC patients (Figure 3E).