MCAM and nonpapillary renal cell carcinoma: Moreover, multivariate Cox regression analysis showed that CD146 expression (HR = 4.655, p = 0.007), Fuhrman grade (HR = 3.472, p = 0.005), and M stage (HR = 3.625, p = 0.004) were independent prognostic factors for ccRCC patients (Table 2).