TREM1 and breast neoplasm: For example, it is possible that in some tumors, TREM-1 signaling could be triggered downstream of TLR activation which may induce a more M1-like polarization in monocytes (24) and therefore contribute to a pro-inflammatory shift in the TME; however, our findings of a lack of robust association between myeloid TREM1 and TLR gene expression suggests that such a phenomenon is not common in breast tumors.