MMP9 and neoplasm: Importantly, similar to short-term Olaparib treatment (Figure 1C), RT-PCR analysis of parental and Olaparib-resistant A2780, OVCAR8, and PEO1 cells showed mRNA upregulation of several essential tumor-promoting genes, such as MMP9, VEGFA, CCND1, and BCL2L1, which are known STAT3 target genes (8) (Figure 2C).