This activity takes place via multiple approaches, including the inhibition of the Silent Information Regulator 1 (Sirt1) expression, increase of the expression of acetylated Forkhead Box O1 (FoxO1) transcription factor, Notch1 targeting, and the p53 protein in endothelial progenitor cells and human cancer cells (72–75). Here, FOXO1 is linked to cancer.