CBL: Casitas B-lineage lymphoma; RNF213: ring finger protein 213; KRIT1: Krev interaction trapped 1; CCM1: cavernous malformations-1; GUCY1A3: guanylate cyclase soluble subunit alpha-3; PHACE: posterior fossa anomalies, hemangioma, arterial anomalies, cardiac anomalies, and eye anomalies; FIRES: febrile infection-related epilepsy syndrome. The gene discussed is RNF213; the disease is hemangioma.