VEGFA and age-related macular degeneration: Twenty-two healthy individuals were enrolled as controls.<h4>Results</h4>A significant decline in systemic vascular endothelial growth factor-A level, from 43 (30-57) pg/ml at baseline to 8 (8-8) pg/ml (<i>p</i> < 0.001) at week one and 17 (8-25) pg/ml (<i>p</i>=0.0054) at week four, was observed in the age-related macular degeneration group.