SNCA and Parkinson disease: Although aggregated α-synuclein is found in homozygous GBAL444P/L444P Gaucher-model mice [98], both the heterozygous models (GBAL444P/WT or GBAD409V/WT) representative of PD do not show any such aggregation [68,99], although α-synuclein levels in general may be elevated [69].