DISC1 and major depressive disorder: Genetic linkage in this pedigree associates with Schz (LOD= 3.6) as well as a broad phenotype (LOD 7.1) for BPD, MDD, and Schz [23,24].An ever growing body of data, summarized below, point to a role for DISC1 in normalcognition, and as such, serves as a useful model for probing underlying changes thatoccur in MMI.