After Spearman correlation analysis, a positive correlation was observed between Gensini score and serum RBP4, hs-CRP, and IL-27 levels in patients with CHD (P < 0.05), which further confirmed that serum RBP4, hs-CRP, and IL-27 levels could accurately reflect the severity of CHD. This evidence concerns the gene IL27 and coronary artery disorder.