After Spearman correlation analysis, a positive correlation was observed between Gensini score and serum RBP4, hs-CRP, and IL-27 levels in patients with CHD (P < 0.05), which further confirmed that serum RBP4, hs-CRP, and IL-27 levels could accurately reflect the severity of CHD. The gene discussed is RBP4; the disease is coronary artery disorder.