To comprehensively illustrate the effect of berberine for diabetes, glucose metabolism-related index (HbA1c, FPG, and 2hPG), insulin resistance-related index (FINS, HOMA-IR, and BMI), lipid profiles (TC, TG, HDL, and LDL), and inflammation index (CRP, IL-6, and TNF-α) were reported, along with the safety including effect of berberine on serum creatinine (SCR), blood urea nitrogen (BUN), and any associated adverse events. This evidence concerns the gene CRP and Insulin resistance.