In the present study, we aimed to investigate the possibility of an association of the plasma levels of SAM and SAH with the severity of lung injury, using some routinely used biomarkers such as D-dimer, C-reactive protein (CRP), interleukin-6 (IL-6), and ferritin and aminothiols, including Hcy and GSH in patients with COVID-19 at admission. The gene discussed is CRP; the disease is COVID-19.