FSHR and polycystic ovary syndrome: Luteolin and emodin can improve the environment of high insulin levels by promoting PI3K/AKT pathway [50, 51] and thus upregulating CYP1B1 gene expression, which is a potential target gene of ZSYTP and PCOS, and CYP1B1 is involved in steroid and lipogenesis and metabolism [52] and also relates to improving the aromatase activity of ovarian granulosa cells in an environment of high insulin levels, which enhanced expression of FSH receptors and increased estrogen produciton.