Studies have shown that Andro treatment can increase DNA fragmentation and reduce Na + -K + -ATPase activity, indicating α-subunit dysfunction and/or mitochondrial membrane damage, and also indicating mitochondrial dysfunction caused by AD, and reducing TGF-β1 and VEGF expression levels inhibits tumor cell proliferation and downregulates PCK to promote lung cancer cell apoptosis [16, 17]. This evidence concerns the gene VEGFA and neoplasm.