AKT1 and central nervous system cancer: MiR-296b is lowly expressed in highly malignant gliomas, which may affect genes related to malignant degree; miR-296 and miR-517cA can inhibit the proliferation of glioma cells, and the expression of miR-7 in glioma is decreased, which inhibits the expression of epidermal growth factor receptor and the Akt pathway [31].