Considering that Pten inactivation in the uterine stroma is observed in Cowden’s disease, but not common in sporadic cases of human EC, these results suggest that Pgr-Cre; Ptenfl/fl mice and Ltf-iCre; Ptenfl/fl mice may mimic hereditary and sporadic cases of EC, respectively. The gene discussed is PTEN; the disease is Cowden disease.