TP53 and neoplasm: These findings are in line with the notion that the KrasWT, which is normally regarded as an oncogene, serves as a relative tumor suppressor gene in the presence of KrasG12D (Zhang et al., 2001), suggesting that Cdkn2a suppression might be less tumorigenic than Trp53 loss in the context of Kras-driven tumorigenesis in gynecological organs.