As embryos of mice with Dicer1 allele deletion died, Otsuka et al. used the mouse model with inefficient Dicer1 allele mutation to study and found that the Dicer1 defect impaired the growth of new capillaries in the ovaries of female mice, resulting in luteal insufficiency and infertility in female mice (Otsuka et al., 2008). The gene discussed is DICER1; the disease is Infertility.