Some studies conducted conditional knockout of Drosha and Dicer in spermatogenic cells of mice testis after birth, and found that the knockout mice were infertile due to impaired spermatogenesis, presenting oligospermia or azoospermia, suggesting that miRNA is involved in regulating spermatogenesis and plays a crucial role (Bernard et al., 2015). This evidence concerns the gene DICER1 and Infertility.