TNF and Familial prostate cancer: GSEA analysis showed that the enriched pathways mainly involved TNF signaling pathway, prostate cancer, necroptosis, fluid shear stress and atherosclerosis, estrogen signaling pathway, IL-17 signaling pathway, NOD-like receptor signaling pathway, neuroactive ligand–receptor interaction, osteoclast differentiation, and Toll-like receptor signaling pathway (Figure 3).