Considering the important roles of BRCA1, BRCA2, CDH1, PTEN, TP53, PIK3CA in BC, we also evaluated these gene expression between gene high-risk and low-risk groups, and observed that the expression of oncogenes such as BRCA1, BRCA2 and CDH1 were significantly higher in high-risk group. The gene discussed is PIK3CA; the disease is breast cancer.