APOE and Alzheimer disease: As the vast literature is available on genomic studies involving different methodologies such as genome-wide studies including linkage, association, and expression (Talwar et al., 2016), previously, we employed an integrative approach combining multiple data sources along with network modeling of protein–protein interactions to identify the candidate genes associated with AD which revealed APOE, EFGR, and ACTB as the hub genes (Talwar et al., 2014).