The exposure of vascular endothelial growth factor receptor 3 (VEGFR3) to vascular endothelial growth factor C (VEGF-C) and VEGF-D has been widely demonstrated as the pivotal molecular event in lymphangiogenesis in unilateral ureteral obstruction (UUO), proteinuria and hypertension caused renal inflammation (13–15). Here, FLT4 is linked to hypertensive disorder.