To reveal the influence of inhibiting CCR7 + cells trafficking on allograft, Masson staining of renal tissues was performed, and it’s been found that this strategy effectively ameliorated tubular interstitial fibrosis and renal atrophy at the week 4 and week 8 posttransplant, as well as significantly increased the percent survival of recipient mice, showing similar results as the strategy of suppressing lymphangiogenesis (Figures 5J, S10). Here, CCR7 is linked to Renal atrophy.