As a danger-associated molecular pattern (DAMP) or adjuvant, oxidized mtDNA would gain access to the cytosol of DCs and activate the STING signal pathway, which subsequently presented irradiated tumor cell-derived antigens to promote the proliferation and differentiation of CD8+ T cells eliciting strong anti-tumor immunity of the irradiated immunogenic cancer cell vaccine (122). Here, CD8A is linked to cancer.