A representative example is that acquired mutations of the STING gene (STING N154S in humans and STING N153S in mice) cause STING–associated vasculopathy with onset in infancy (SAVI), characterized by vasculopathy, ulcerative skin lesions, and pulmonary fibrosis, spontaneous colitis (86–91). The gene discussed is STING1; the disease is STING-associated vasculopathy with onset in infancy.