Due to the abnormal phagocytic function of phagocytes or the degradation defects of phagocytic components, the tumor cell-derived DNA or the secondary messenger exist excessively in phagocytes, such as DCs and tumor-associated macrophages (TAMs), which then triggers the activation of the cGAS-STING signal pathway to induce host anti-tumor immune responses. Here, CGAS is linked to neoplasm.