The researchers found that the c-di-GMP triggered the ubiquitination and stabilization of STING to induce a significant increase of IFN-γ-producing Th1 cells and reduction of Treg cells, promoting the progression of colitis (96), which proved that STING could regulate the differentiation of T cells in the SAVI model to affect the process of the disease once again. This evidence concerns the gene STING1 and STING-associated vasculopathy with onset in infancy.