Similarly, the related study found that c-di-GMP could produce strong CD4+ T cells and CD8+ T cells responses, which were of great significance for the immunotherapy of related infectious diseases in a STING–NF-κB–TNF-α pathway manner, including H5N1 influenza, Staphylococcus aureus, and Streptococcus pneumoniae (134, 135). The gene discussed is STING1; the disease is infectious disease.