In the bacterial sepsis and SARS-CoV-2 with secondary infection groups, TNF-alpha expression with LPS and IL-7 stimulation decreased significantly over time, as tested by a generalized estimating equation (p=0·03 and p<0·01, respectively); this was not observed for patients with SARS-CoV-2 and no secondary infection (p=0·26). This evidence concerns the gene TNF and bacterial infectious disease with sepsis.