However, those functionally active anti-AT1R antibodies were not only detected in rheumatic disorders but also in other disorders as shown for chronic liver disorders; thus they were present in 49% of patients with autoimmune liver diseases (23% stimulatory, 26% inhibitory) and even 70% of patients with viral or toxic hepatitis (33% stimulatory, 37% inhibitory); especially in patients with non-autoimmune liver diseases the inhibitory antibodies were more frequently found than in SSc patients (and healthy controls) (Table 1). Here, AGTR1 is linked to systemic sclerosis.