In AAE-C1-INH type I, it was reported that a monoclonal component either of unknown significance or due to a myeloma that had C1-inhibitor-binding ability (generated by lymphoproliferative onco-hematologic or immunoregulatory disorders) consumes the C1 complement complex including C1q and C1-INH. The gene discussed is SERPING1; the disease is acquired angioedema.