Eight downregulated miRNAs (of which miR-511-5p, miR-30c-5p, miR-27b-3p, miR-150-5p and miR-139-5p were validated) and 3 upregulated miRNAs resulted in a partially activated network which included TLR4, IL6, TP53 and STAT1 suggesting a central role for these transcripts in COVID-19 induced lung injury. The gene discussed is TLR4; the disease is COVID-19.