RNF20 and colitis: The susceptibility of RNF 20 heterozygote (Rnf20+/-) mice to colitis and inflammatory-associated tumour was increased, likely because RNF20 deletion in non-cancerous epithelial cells, intestinal organoids, and innate immune cells promoted p65 binding to the κB site, leading to the transcriptional activation of NF-κB target genes (101).