However, the critical importance of these pathways to fundamental B cell biology likely influences other autoimmune conditions as well, including systemic lupus erythematosus, skin disorders, gut inflammation, etc. Thus, the present study raises the prospect of targeting B cell activation influenced by RIP1 and caspase-8 pathways to limit numerous different human autoinflammatory diseases. The gene discussed is CASP8; the disease is systemic lupus erythematosus.