GPT and infection: Moreover, serum titres of liver enzymes showed an increased AST/ALT ratio over infection-treatment cycles gradually progressing after 15 weeks in animals undergoing one or two cycles of infection-treatment (Figure 4B, Lower panel) to achieve significance in longer term exposure after three infection-treatment cycles (Figure 4C, lower panel, p=0.038) indicating overall an increased hepatotoxicity after more prolonged exposure in 3 cycles of infection-treatment.