On the other hand, a prospective study of the systemic sclerosis interstitial lung disease (SSc-ILD) demonstrated that serum KL-6 >1,273 U/ml was the most reliable predictor of end-stage lung disease development (OR 51.2; 95% CI, 7.6–343) by multivariate analysis. The gene discussed is MUC1; the disease is systemic sclerosis.