As most flavivirus infection exhibited similar immunological changes, we detected the expression of NLRP12 in hMDMs with other flavivirus (JEF, YFV and ZIKV) infection as well as viral mimic polyinosinic-polycytidilic acid [poly (I:C)] treatment, which verified that reduced expression of NLRP12 is a generalized phenomenon in flavivirus infection (Figures 1F–I). Here, NLRP12 is linked to infection.