Compared with healthy controls, fewer circulating CD3+CD45RA+naïve (Tnaïve) and CD4+CD25- conventional T cells (Tconv) were found (107); a significantly higher percentage of CD25+ Treg cells from both the CD4+ and CD8+ lineages were found in PBMCs and TILs from NPC patients. This evidence concerns the gene CD8A and nasopharyngeal carcinoma.