Single-cell RNA sequencing and TCR repertoire sequencing analysis from more than 170,000 cells from 10 NPC tumours and matching PBMCs revealed 53 cell subtypes including tumour-infiltrating CD8+ T cells, Treg, and DCs, as well as malignant cells with different Epstein–Barr virus infection status. Here, CD8A is linked to nasopharyngeal carcinoma.