Recently, our group reported that the PS receptors T cell immunoglobulin mucin domain-containing molecule 3 (Tim-3) and Tim-4 are elevated in liver macrophages in murine steatohepatitis, and their knockout leads to an increased production of ROS, IL-1β, and IL-18 in macrophages, with aggravation of steatosis and inflammation. Here, IL1B is linked to steatosis.