It has been reported that Caspase-1 activity and mature IL-1β levels are significantly increased in steatohepatitis models (104), and NLRP3 inflammasome activation aggravates hepatic steatosis, liver inflammation, and fibrogenesis, supporting the contribution of NLRP3 inflammasome to pathogenesis of fatty liver disease (105). The gene discussed is NLRP3; the disease is Hepatic steatosis.