This factor impairs plasmacytoid dendritic cell recruitment by reducing interferon (IFN)-1 levels at the site of infection and destabilizes DNA via the host protein HMGB1 (high mobility group box 1), which may decrease IFN-1 levels at the site of infection (1 levels at the site of infection (Uchiyama et al., 2012; Keller et al., 2019). The gene discussed is HMGB1; the disease is infection.