Thus, AST to ALT ratio may be a good indicator for frailty and sarcopenia in older patients (38) and multivariate logistic regression model also showed that fasting insulin (OR=0.919, [95%CI: 0.878-0.922] P=0.000) and AST to ALT ratio (OR=2.771, [95%CI: 1.544-2.342] P=0.000) were risk factors for sarcopenia. The gene discussed is INS; the disease is sarcopenia.