Arguably, the residual differences displayed by pAS160-S318 and pSGK1-S422 [subcutaneous fat (29)] or by decreased NDRG1 phosphorylation at Thr346 (omental fat, this study, see below) may reflect the altered basal state of insulin/mTOR signaling in T2DM versus NGT subjects. This evidence concerns the gene MTOR and type 2 diabetes mellitus.