Therefore, we speculated that long-term malignant psychological stress state may lead to BBB destruction in SLE patients with anxiety, and effector memory Th/Treg cells and effector Th/Treg cells increase the secretion of more IFN-γ and IL-6 into BBB, enhancing the central inflammatory response, and thus causing anxiety. The gene discussed is IFNG; the disease is systemic lupus erythematosus.