Recent studies have also shown that HSPG2 is closely related to neuropsychiatric disorders, and Clement et al. found that a single nucleotide polymorphism of HSPG2 was positively associated with tardive dyskinesia occurrence in SCZ patients (49) and another study showed that a decreasing expression of HSPG2 was observed in both frontotemporal dementia and amyotrophic lateral sclerosis (50). This evidence concerns the gene HSPG2 and frontotemporal dementia.